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SIRT6 depletion increased the sensitivity of HCC cells to chemotherapeutics. (A,B) The cells depleted SIRT6 were exposed to doxorubicin (1 μg/mL), cisplatin (2 μg/mL), and sorafenib (4 μg/mL) for 48 h, respectively. The apoptosis was analyzed by flow cytometer with Annexin V/PI in Huh-7 (A) and SK-Hep-1 (B) cells. ∗P < 0.05 vs. shCont.
