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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: Free Radic Biol Med. 2018 Feb 2;117:99–109. doi: 10.1016/j.freeradbiomed.2018.01.023

Figure 5. Concomitant overexpression of ECSOD and knockdown of xCT in prostate cancer stromal cells (WPMY1) significantly inhibits PC3 invasion and alters the redox state in the TME.

Figure 5

(A) Western blot shows overexpression of ECSOD in the media and in stromal cells by AdhSOD3 (300 MOI) and concomitant down-regulation of the xCT protein by siRNA. (B) Cell invasive ability of PC3 cells that was co-cultured with WPMY1 cells or WPMY1 cells with overexpression of ECSOD and knockdown of xCT. *p-value ≤ 0.05. (C) H2O2 level and (D) redox state in the media of the co-culturing system in WPMY1 cells with overexpression of ECSOD and concomitant knockdown of xCT. *p-value ≤ 0.05 compared with the control.