Table 1.
Effects of EE2 and BPA on splenocyte proliferation in response to LPS, PWM or anti-CD3/CD28 stimulation.
| PND 90 | PND 6 Month | PND 1 Year | |||||
|---|---|---|---|---|---|---|---|
|
|
|
|
|||||
| Activation | Sex | EE2 | BPA | EE2 | BPA | EE2 | BPA |
| LPS | F | ↓0.5 | N | ↑0.05 ↑0.5 |
N | N | ↑2500 |
| M | N | N | N | N | ↑0.5 | ↑2.5 ↑2500 ↑25000 |
|
|
| |||||||
| PWM | F | N | ↓25000 | ↑0.05 | ↑25 ↑2500 |
↓0.05 | N |
| M | ↓0.05 | N | ↓0.5 | ↓2.5 ↓250 ↓2500 |
↑0.05 ↑0.5 |
↑2.5 ↑25 ↑2500 ↑25000 |
|
|
| |||||||
| Anti-CD3/CD28 | F | N | N | N | N | ↓0.05 | ↓2.5 |
| M | N | N | ↓0.5 | N | N | N | |
F: female; M: male. N indicates no significant difference compared to control groups. ↑ indicates increase and ↓ indicates decrease. Numbers designate the dose levels (μg/kg bw/day) at which significant changes were observed.