Table 2.
Effects of EE2 and BPA on IgM responses at 72 h after LPS or PWM activation.
| PND 90 | PND 6 Month | PND 1 Year | ||||||
|---|---|---|---|---|---|---|---|---|
|
|
|
|
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| Endpoints | Activation | Sex | EE2 | BPA | EE2 | BPA | EE2 | BPA |
| Intracellular IgM | LPS | F | N | ↑2500 | N | N | N | N |
| M | N | ↓2.5 | N | N | N | N | ||
|
| ||||||||
| PWM | F | N | ↑25000 | N | N | N | N | |
| M | N | N | N | N | N | N | ||
|
| ||||||||
| Secreted IgM | LPS | F | N | N | N | N | N | N |
| M | N | N | N | N | N | N | ||
|
| ||||||||
| PWM | F | N | N | ↑0.5 | N | N | N | |
| M | ↑0.05 | N | N | N | N | N | ||
F: female; M: male. N indicates no significant difference compared to control groups. ↑ indicates increase and ↓ indicates decrease. Numbers designate the dose levels (μg/kg bw/day) at which significant changes were observed.