Figure 6.
(A–B) Representative immunoblots and analysis of phosphorylated LKB1 and total LKB1. (C) Cardiac levels of ATP, ADP, and AMP. (D) Ratio of AMP to ATP. (E–F) Representative immunoblots and analysis of PP2A subunits. (G–H) Representative immunoblots and analysis from the modified biotin switch assay examining the sulfhydration status of PP2A subunits. (I) PP2A activity. All samples were collected from hearts of mice administered standard diet (Chow) or diet supplemented with SG-1002 (SG-1002; 20mg/kg/day) for 4 weeks. Values are means ±SEM. *p<0.05 and ***p<0.001 vs. Chow.