Skip to main content
. Author manuscript; available in PMC: 2019 Feb 15.
Published in final edited form as: Neuroimage. 2017 Oct 31;167:438–452. doi: 10.1016/j.neuroimage.2017.10.063

Table 3.

Average volumes (in milliliters; ml) in thalamic subnuclei.

CIS-NC CIS RRMS-NC RRMS SPMS-NC SPMS
GT
Sum (CI) 16.81 ± 0.13
(0.416)		 14.90 ± 1.72
(0.531)		 16.07 ± 1.31
(0.407)		 14.00 ± 1.85
(0.572)
Left (CI) 8.22 ± 0.64
(0.200)		 8.05 ± 0.71
(0.221)
Right (CI) 8.45 ± 0.53
(0.165)		 8.17 ± 0.68
(0.211)
Difference (d) −0.17 (−0.25) / −0.28 (−0.47) −1.91 (−1.2) −2.07 (−1.1)
p 0.28 / 0.043* <0.001* <0.001*
PUL
Left (CI) 2.14 ± 0.32
(0.0982)		 2.05 ± 0.30
(0.0918)		 2.22 ± 0.30
(0.0925)		 1.84 ± 0.35
(0.109)		 2.05 ± 0.27
(0.0833)		 1.71 ± 0.38
(0.117)
Right (CI) 2.35 ± 0.29
(0.0904)		 2.20 ± 0.33
(0.101)		 2.39 ± 0.29
(0.0885)		 2.01 ± 0.35
(0.109)		 2.25 ± 0.29 (0.0899) 1.88 ± 0.41 (0.128)
Difference (d) −0.09 (−0.30) / −0.15 (−0.49) −0.38 (−1.1) / −0.38 (−1.2) −0.34 (−1.0) / −0.37 (−1.0)
p 0.19 / 0.034* <0.001* / <0.001* <0.001* / <0.001*
MNR
Left (CI) 0.79 ± 0.12
(0.0380)		 0.77 ± 0.13
(0.0405)		 0.78 ± 0.13
(0.0395)		 0.69 ± 0.11
(0.0345)		 0.76 ± 0.15
(0.0474)		 0.64 ± 0.14
(0.0427)
Right (CI) 0.87 ± 0.10
(0.0326)		 0.85 ± 0.12
(0.0385)		 0.85 ± 0.16
(0.0500)		 0.75 ± 0.15
(0.0461)		 0.81 ± 0.14
(0.0424)		 0.67 ± 0.12
(0.0365)
Difference (d) −0.02 (−0.21) / −0.02 (−0.15) −0.09 (−0.75) / −0.10 (−0.60) −0.12 (−0.82) / −0.14 (−0.82)
p 0.36 / 0.50 0.0013* / 0.012* <0.001* / <0.001*
LNR
Sum (CI) 2.063 ± 0.187
(0.0580)		 2.035 ± 0.22
(0.0692)		 2.10 ± 0.23
(0.0717)		 1.83 ± 0.26
(0.0817)		 2.00 ± 0.21
(0.0660)		 1.69 ± 0.29
(0.0901)
Difference (d) −0.024 (−0.086) −01.26 (−1.0) −0.36 (−1.1)
p 0.56 <0.001* <0.001*

Values are reported as mean ± standard deviation. CI denotes the 95% confidence interval, d is Cohen’s effect size. For each region, values are reported either as bi-hemispheric sum or for each hemisphere individually, depending on the statistical significance of differences between hemispheres. If sample distributions were different in either the patient or the control groups, hemispheres were analyzed separately for both groups. All sample distributions were normal, except the left and right PUL in SPMS (compared using Wilcoxon test). For the comparison of hemispheres, differences are reported as left / right. The p-values were determined by univariate ANCOVA adjusted for sex (we found no significant interactions with sex except for a trend in the right MNR with p=0.027). Bonferroni corrected thresholds for statistical significance were 0.05/7=0.0071 for CIS, 0.05/6=0.0083 for RRMS and SPMS. * indicates trends, statistical significance after Bonferroni correction is indicated by ** and boldface.