Table 3.
Correlations among cognition measured by using different methods and depression
| Responses analyzed together for all three HD groups
| ||||||
|---|---|---|---|---|---|---|
| EF | GC | Self-rated Composite | PROMIS Depression | Objective Composite | Clinician- Rated Composite | |
| Neuro-QoL Executive Function (EF) | -- | .739** | .735** | −.410** | .513** | .418** |
| Neuro-QoL General Concerns (GC) | -- | .671** | −.493** | .360** | .342** | |
| Self-rated Composite | -- | −.408** | .522** | .376** | ||
| PROMIS Depression | -- | −.163** | −.168** | |||
| Objective Composite | -- | .388** | ||||
| Clinician-Rated Composite | -- | |||||
| Responses analyzed together for all three HD groups controlling for depression
| |||||
|---|---|---|---|---|---|
| EF | GC | Self-rated Composite | Objective Composite | Clinician-Rated Composite | |
| Neuro-QoL Executive Function (EF) | -- | .676** | .682** | .495** | .388** |
| Neuro-QoL General Concerns (GC) | -- | .591** | .325** | .302** | |
| Self-rated Composite | -- | .506** | .342** | ||
| Objective Composite | -- | .371** | |||
| Clinician-Rated Composite | -- | ||||
| Responses by HD disease-stage
| ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Prodromal | Early-Stage | Late-Stage | ||||||||||||||||
| EF | GC | Self | Dep | Obj | Clin | EF | GC | Self | Dep | Obj | Clin | EF | GC | Self | Dep | Obj | Clin | |
| EF | -- | .790** | .704** | −.502** | .187* | .483** | -- | .764** | .599** | −.471** | .199** | .233** | -- | .492** | .634** | −.301** | .150 | .069 |
| GC | -- | .654** | −.474** | .143 | .421** | -- | .655** | −.517** | .193** | .264** | -- | .610** | −.482** | −.007 | .040 | |||
| Self | -- | −.483** | .166* | .401** | -- | −.469** | .275** | .235** | -- | −.350** | .202 | .099 | ||||||
| Dep | -- | -.080 | −.259** | -- | −.158* | .071 | -- | .036 | −.053 | |||||||||
| Obj | -- | .233** | -- | .008 | -- | .232 | ||||||||||||
| Clin | -- | -- | -- | |||||||||||||||
Note. HD = Huntington disease; EF: Neuro-QoL Executive Function; GC: Neuro-QoL General Concerns; Self: Self-rated composite; Dep: PROMIS Depression; Obj: Objective composite; Clin: Clinician-rated composite.
**
p<0.01