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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: Free Radic Biol Med. 2018 Jan 31;117:90–98. doi: 10.1016/j.freeradbiomed.2018.01.021

Figure 3.

Figure 3

Aggregation causes iNOS to lose catalytic function. (A) NO production from iNOS expressed in RAW 264.7 cells in the absence and presence of Hsp90 and proteasome inhibitors. Data are mean ± SE. ** P < 0.01 vs. control, n=3. (B, C) Under Hsp90 inhibition, the catalytic activity of iNOS was largely lost after aggregation. ** P < 0.01 vs. control, n = 4.