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Schematic diagram depicting iNOS aggregation and degradation in Hsp90-inhibited cells. Hsp90 inhibition triggers the dissociation of Hsp90 from iNOS and subsequent iNOS aggregation. SPSB2 interacts with iNOS and recruits E3 ligase to ubiquitinate aggregated iNOS. Ubiquitinated iNOS aggregates are degraded by the proteasome.
