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. 2018 Mar 7;9:335. doi: 10.3389/fimmu.2018.00335

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Copyright © 2018 Zhao, Xu, Luo, Wei, Wang, Shi and Ren.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Distribution of AdHu5 and AdC68 neutralizing antibody (NAb) titers in positive samples from lung squamous cell carcinoma and adenocarcinoma subjects. NAb titers were stratified in the following tiers: low titer (≥20 and ≤160), medium titer (≥320 and ≤640), and high titer (≥1,280). For the positive samples from lung squamous cell carcinoma patients, the AdHu5 NAb titers from low to high were 48.28, 37.93, and 13.79%, respectively, while the AdC68 NAb titers from low to high were 92.86, 7.14, and 0%, respectively; this was significantly different from AdHu5 (P < 0.05). For positive samples from lung adenocarcinoma patients, the AdHu5 NAb titers from low to high were 74.19, 22.58, and 3.23%, respectively, while all of the positive AdC68 NAb sample titers were lower or equal to 160. However, no significant difference in the distribution of the two vectors in lung adenocarcinoma patients was observed (P > 0.05).