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. 2018 Mar 7;9:456. doi: 10.3389/fimmu.2018.00456

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Copyright © 2018 Díaz-Viraqué, Chiribao, Trochine, González-Herrera, Castillo, Liempi, Kemmerling, Maya and Robello.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TcOYE overexpressing parasites present differential viability to benznidazole (Bzn), nifurtimox (Nfx), or hydrogen peroxide (H₂O₂). (A) Viability percentages of transfected parasites challenged with different concentrations of Bzn. (B) Viability percentages of transfected parasites challenged with different concentrations of Nfx. (C) Viability percentages of transfected parasites challenged with different concentrations of hydrogen peroxide. The percentages of cell viability are normalized against parasites without treatment. Values are the means of three independent assays performed in quadruplicate. Asterisks represent statistical significance (two tailed Student’s t-test).