Table 1.
Frequency of transduced cells by cell type, vector, and spinal cord region in samples harvested at P10.
| IDLV-CMV-GFP-VSV-G | IDLV-CMV-GFP-Rabies | IDLV-CMV-GFP-RRV | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | GFP +/ChAT + | Total ChAT + | % | N | GFP +/ChAT + | Total ChAT + | % | N | GFP +/ChAT + | Total ChAT + | % | |
| Cervical | 3 | 259 | 259 | 100 | 3 | 234 | 234 | 100 | 3 | 243 | 243 | 100 |
| Thoracic | 3 | 146 | 146 | 100 | 3 | 151 | 151 | 100 | 3 | 137 | 137 | 100 |
| Lumbar | 3 | 264 | 264 | 100 | 3 | 223 | 223 | 100 | 3 | 237 | 237 | 100 |
| N | GFP +/NeuN + | Total NeuN + | % | N | GFP +/NeuN + | Total NeuN + | % | N | GFP +/NeuN + | Total NeuN + | % | |
| Cervical | 3 | 74 | 463 | 15.9 ± 6 | 3 | 163 | 455 | 35.8 ± 3 | 3 | 66 | 477 | 13.8 ± 4 |
| Thoracic | 3 | 61 | 441 | 13.8 ± 5 | 3 | 151 | 413 | 36.5 ± 4 | 3 | 51 | 411 | 12.4 ± 3 |
| Lumbar | 3 | 73 | 487 | 14.9 ± 6 | 3 | 156 | 447 | 34.8 ± 7 | 3 | 59 | 461 | 12.7 ± 4 |
| IDLV-CMV-GFP-Mokola | scAAV9-CAG-GFP | |||||||
|---|---|---|---|---|---|---|---|---|
| N | GFP +/ChAT + | Total ChAT + | % | N | GFP +/ChAT + | Total ChAT + | % | |
| Cervical | 3 | 262 | 262 | 100 | 3 | 97 | 271 | 35.7 ± 7 |
| Thoracic | 3 | 133 | 133 | 100 | 3 | 86 | 263 | 32.6 ± 4 |
| Lumbar | 3 | 243 | 243 | 100 | 3 | 101 | 266 | 37.9 ± 4 |
| N | GFP +/NeuN + | Total NeuN + | % | N | GFP +/NeuN + | Total NeuN + | % | |
| Cervical | 3 | 46 | 419 | 10.9 ± 7 | 3 | 69 | 437 | 15.7 ± 5 |
| Thoracic | 3 | 43 | 403 | 10.6 ± 6 | 3 | 55 | 410 | 13.4 ± 3 |
| Lumbar | 3 | 51 | 431 | 11.8 ± 4 | 3 | 67 | 453 | 14.7 ± 5 |