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Binding and thermodynamic parameters of binding between neratinib and BSA.
| T(K) | R | Log Kb ± SD | Kb ± SD × 104 (L mol−1) | n | ΔG (kJ mol−1) | ΔH (kJ mol−1) | ΔS (Jmol−1·K−1) |
|---|---|---|---|---|---|---|---|
| 298 | 0.9938 | 4.909 | 8.10 ± 0.20 | 1.02 | −27.93 | −76.9 | −164 |
| 303 | 0.9905 | 4.653 | 4.50 ± 0.24 | 0.96 | −27.11 | ||
| 308 | 0.9902 | 4.383 | 2.42 ± 0.11 | 0.92 | −25.96 |
