Figure 4.
Effects of derivative 47 (in red) on S. aureus bacteria survival in the hearts and livers of mice (n = 10 for each group), challenged with 1.1 × 109 CFU of Mu50 and 1.8 × 108 CFU of NRS271 in vivo section, respectively. P = pretreatment, drugs or compounds were intraperitoneally administered 24 h before infection in contrast with the normal treatment (in which drugs or compounds were administered 6 h after infection). Each symbol represents the value for an individual mouse. Horizontal bars indicate the observation means, and dashed lines mark the limits of detection. Statistical significance was determined by the Mann–Whitney test (two-tailed): *p < 0.05, **p < 0.01, ***p < 0.001, and ns indicates no significant difference.