Table 1. Anti-inflammatory and Antiproliferative Activity Data.

				anti-inflammatory activity			%cytotoxicity/antiproliferative activity
comp ID	subn. (Ar)	% yield	conc	% TNF- α inh	% IL-6 inh	% tox	A-549	ACHN	MDA-MB-231	MIA-PACA-2
4a	phenyl	87	1	0	0	0	34	61	0	45
			10	0	66	13	73	82	61	41
4b	2-Cl phenyl	85	1	0	0	0	12	48	0	26
			10	12	0	23	81	82	51	69
4c	3-Cl phenyl	86	1	0	0	3	71	81	53	63
			10	44	74	23	52	68	18	38
4d	4-Cl phenyl	84	1	0	0	0	19	45	0	21
			10	42	75	37	44	69	12	63
4e	2-NO2 phenyl	67	1	0	0	0	21	49	0	35
			10	36	78	6	36	68	18	51
4f	3-NO2 phenyl	67	1	11	0	17	74	79	53	65
			10	43	79	30	71	83	65	70
4g	4-NO2 phenyl	77	1	0	0	4	0	9	0	15
			10	27	0	28	77	75	50	64
4h	4-F phenyl	82	1	0	0	0	0	27	0	16
			10	0	66	6	22	50	24	45
4i	3-Br phenyl	87	1	2	0	8	59	73	45	61
			10	38	82	24	78	75	54	70
4j	3-OC6H5 phenyl	93	1	18	0	16	70	69	47	66
			10	34	52	28	67	71	51	72
4k	4-SCH3 phenyl	88	1	0	0	9	0	0	0	16
			10	28	37	21	5	2	10	17
4l	3-OH phenyl	74	1	5	0	0	0	0	0	17
			10	4	11	0	5	18	12	29
4m	4-OH phenyl	78	1	0	0	0	13	55	23	55
			10	0	0	23	76	83	77	83
4n	4-N(CH3)2 phenyl	88	1	0	0	0	10	41	20	34
			10	0	0	5	16	39	22	31
4o	2-OCH3 phenyl	91	1	0	0	0	14	37	22	24
			10	0	32	14	16	37	18	21
4p	4-OCH3 phenyl	93	1	0	0	18	73	78	70	80
			10	0	77	3	79	85	81	84
4q	3,4-DiOCH3 phenyl	93	1	0	0	0	23	38	20	40
			10	0	43	13	24	38	24	50
4r	9-anthracyl	90	1	0	0	8	10	25	19	40
			10	0	0	29	58	65	69	66
4s	3-OC2O5, 4-OH phenyl	83	1	0	0	0	0	6	12	27
			10	0	0	67	78	81	88	68
4t	3-indolyl	82	1	0	0	6	8	27	16	18
			10	0	0	7	69	71	67	77
4u	3-OCH3 phenyl	93	1	0	0	–6	70	67	66	76
			10	0	33	23	69	73	75	75