Table 2. Anti-inflammatory and Anticancer Activity Dataa.
| anti-inflammatory activity (IC50, μM) |
anticancer activity
(IC50, μM) |
|||||||
|---|---|---|---|---|---|---|---|---|
| comp ID | TNF-α | IL-6 | toxicity | ACHN | Panc-1 | HCT-116 | H-460 | Calu-1 |
| 4a | 4.9 | <0.03 | >10 | 2.8 | 1.5 | 1.0 | 1.3 | 1.2 |
| 4c | 0.5 | 0.2 | >10 | 0.1 | 1.0 | 0.3 | 0.3 | 0.5 |
| 4f | 0.3 | 0.25 | >10 | 1.6 | 2.5 | 6.6 | 1.9 | 1.1 |
| 4i | 0.5 | 0.08 | 10 | 0.9 | 0.8 | 0.9 | 0.8 | 0.8 |
| 4j | 0.2 | 0.2 | 11 | 3.4 | 4.7 | 5.1 | 1.4 | 1.8 |
| 4m | 10 | 4 | 30 | 1.8 | 1.9 | 0.6 | 1.2 | 1.1 |
| 4p | 12.8 | 1.7 | 30 | >20 | >20 | >20 | >20 | >20 |
| 4t | 11 | 1.4 | 6.8 | >20 | >20 | >20 | >20 | >20 |
| 7 HF (1 μM) | 44 | 58 | 0 | |||||
| dexamethasone 1 μM | 40 | 55 | 0 | |||||
| flavopiridol 700 nM | 71 | 78 | 71 | 88 | 74 | |||
| gemcitabine 500 nM | 73 | 74 | 73 | 71 | 79 | |||
a
ACHN, renal cancer cell line; Panc1, pancreas cancer cell line; HCT-116, colon cancer cell line; H-460, nonsmall cell lung carcinoma cell line; Calu-1, lung cancer cell line.