. 2018 Feb 21;9(3):238–243. doi: 10.1021/acsmedchemlett.7b00512

Table 5. Biochemical and ADME Profiling of Compounds 23, 33, 34, 46, and 47^a.

Cmpd	USP7 IC₅₀ (μM)	HLM/MLM CL_hep	logD_7.4/K_sol	Caco-2 P_app A/B
23	0.030	19/84	2.3/175	1.93
33	0.040	19/86	1.7/200	0.15
34	0.006	18/62	–0.1/191	0.28
46	0.087	11/34	0/200	0.26
47	0.022	7/28	0.1/179	0.14

See Supporting Information for assay conditions. HLM/MLM units: mL/min/kg. K_sol units: μM. Caco-2 units: 10^–6 cm/s

Table 5. Biochemical and ADME Profiling of Compounds 23, 33, 34, 46, and 47a.