Table 6. Pharmacokinetic Profile of Compounds 46 and 47 in Male CD-1 Mice.

Routea	Cmpd	Cmaxb	AUCallc	t1/2d	CLe	Vssf
i.v.	46	4035	1700	1.1	13	0.4
	47	2808	516	1.0	32	0.9
i.p	46	3430	3002	1.1	-	-
	47	2876	1904	0.8	-	-

^ai.v., 46 1.3 mg/kg, 47 0.9 mg/kg in 2% DMSO in 20% aq. 2-hydroxypropyl-β-cyclodextrin; i.p., 46 6.2 mg/kg, 47 5.7 mg/kg in saline.

^bng/mL.

^cng·h/mL.

^dhr.

^emL/min/kg.

^fL/kg.