Table 2. ALT and ASAT Activity after the Administration of 2d, 2f, and Reference Compound Tacrine (30 mg/kg)a.
ALT (U/L) |
AST (U/L) |
|||||
---|---|---|---|---|---|---|
group | 8 h | 22 h | 36 h | 8 h | 22 h | 36 h |
control | 35 ± 8.4 | 39 ± 9.4 | 30 ± 8 | 120 ± 20 | 120 ± 20 | 120 ± 13 |
tacrine | 32 ± 4.9 | 25 ± 7 | 25 ± 7 | 130 ± 22 | 120 ± 30 | 110 ± 28 |
2d | 25 ± 7.9 | 31 ± 12 | 30 ± 4 | 110 ± 24 | 120 ± 19 | 130 ± 32 |
2f | 28 ± 7.6 | 29 ± 7.9 | 29 ± 7 | 110 ± 24 | 120 ± 24 | 120 ± 21 |
Values were expressed as the mean ± SD (n = 6).