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. 2018 Feb 9;9(3):171–176. doi: 10.1021/acsmedchemlett.7b00463

Table 2. ALT and ASAT Activity after the Administration of 2d, 2f, and Reference Compound Tacrine (30 mg/kg)a.

  ALT (U/L)
AST (U/L)
group 8 h 22 h 36 h 8 h 22 h 36 h
control 35 ± 8.4 39 ± 9.4 30 ± 8 120 ± 20 120 ± 20 120 ± 13
tacrine 32 ± 4.9 25 ± 7 25 ± 7 130 ± 22 120 ± 30 110 ± 28
2d 25 ± 7.9 31 ± 12 30 ± 4 110 ± 24 120 ± 19 130 ± 32
2f 28 ± 7.6 29 ± 7.9 29 ± 7 110 ± 24 120 ± 24 120 ± 21
a

Values were expressed as the mean ± SD (n = 6).