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Top row: Macrocycles 1, 2, and 6 (A, B, and C, respectively) aligned with the conformation of NT (8–13) within the crystal structure of NTS1 (green). Bottom row: Macrocycles 7, 8, and 9 (D, E, and F, respectively) docked into NTS1. NT (8–13) (green) is shown for comparison. Molecular graphics were performed with the UCSF Chimera package.43
