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. Author manuscript; available in PMC: 2018 May 24.
Published in final edited form as: Sci Transl Med. 2017 May 24;9(391):eaal3226. doi: 10.1126/scitranslmed.aal3226

Fig. 1. Working principle of the plasmon sensor chip (NPS) for tumor derived extracellular vesicles.

Fig. 1

(A) EV binding to the nanopore surface via monoclonal antibody immobilized on the gold surface causes a spectral shift of light transmitted through the nanopores. (B) The spectral shift of resonance peak in light transmission is measured to quantify the amount of EVs captured on the nanopore surface. a.u., arbitrary unit. (C) Scanning electron micrographs (SEMs) show the periodically arranged nanopore array and EVs captured on the surface. Each nanohole has a diameter of 200 nm and a periodicity of 500 nm.