Table 1. Summary of patient cohorts.
Characteristic | Training cohort | Prospective Cohort | Total | ||
---|---|---|---|---|---|
Malignant | Benign | Malignant | Benign | ||
Total cases | 22 | 10 | 82 | 21 | 135 |
| |||||
Subtypes | |||||
| |||||
PDAC untreated | 13 | - | 22 | - | 35 |
| |||||
PDAC neoadjuvant tx | 9 | - | 24 | - | 33 |
| |||||
IPMN inter/high grade | - | - | 13 | - | 13 |
| |||||
NET | - | - | 12 | - | 12 |
| |||||
Other cancer | - | - | 11 | - | 11 |
| |||||
Benign cystic tumor | - | - | - | 5 | 5 |
| |||||
Pancreatitis | - | - | - | 8 | 8 |
| |||||
Controls | - | 10 | - | 8 | 18 |
| |||||
Age | |||||
| |||||
Median | 68 | 48 | 65 | 57 | 63 |
| |||||
Range | 47–88 | 23–82 | 17–84 | 19–91 | 17–91 |
| |||||
Sex | |||||
| |||||
Male | 8 | 4 | 47 | 14 | 73 |
| |||||
Female | 14 | 1 | 40 | 14 | 69 |
| |||||
CA19-9 | |||||
| |||||
PDAC untreated | 1148 (1–6684) | - | 1,006 (1–10,625) | - | 1064 (1–10,625) |
| |||||
PDAC neoadjuvant tx | 2258 (19–17,101) | - | 657 (4–7,730) | - | 1175 (4–17,101) |
| |||||
IPMN | - | - | 10.6 (1–26) | - | 10.6 (1–26) |
| |||||
CEA | |||||
| |||||
PDAC untreated | 7.0 (2–12) | - | 3.4 (0.6–22.1) | - | 5.0 (0.6–22.1) |
| |||||
PDAC neoadjuvant tx | 11.0 (1–53) | - | 56.4 (0.7–1003) | - | 40 (0.7–1003) |
| |||||
IPMN | - | - | 2.1 (0.7–3.3) | - | 2.1 (0.7–3.3) |
| |||||
Stage | |||||
| |||||
I | 0 | - | 10 | - | 10 |
| |||||
II | 1 | - | 42 | - | 43 |
| |||||
III | 5 | - | 5 | - | 10 |
| |||||
IV | 16 | - | 10 | - | 26 |
| |||||
Co-therapies PDAC | |||||
| |||||
Folforinox/XRT | 4 | - | 21 | - | 25 |
| |||||
Gemcitabine | 5 | - | 1 | - | 6 |
| |||||
Other | - | - | 2 | - | 2 |