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Early attenuation of the retinal vasculature and variable pigment migration in the rapid-onset chorioretinopathy (ROC) phenotype of ABCA4 disease. (A) Thinning of the retinal vasculature (dotted boxes) is apparent as early as the third decade and can be accompanied by a range of pigment migration (white arrowheads) from early nummular (B, C) to advanced (D) bone-spicule deposition.
