Table 3. Intravenous (i.v.) and Oral (p.o.) Pharmacokinetic Profiles of Compound 36 in Rats^a.

route	i.v.b	p.o.c
Cmax (μg/L)	1000.37	926.40
Tmax (h)	0.083	1.67
AUC(0-t) (μg/L·h)	1199.17	3520.79
AUC(0-∞) (μg/L·h)	1223.82	3765.71
T1/2 (h)	1.65	1.96
MRT(0-t) (h)	1.17	2.60
Cl (L/h/kg)	1.64
Vz (L/kg)	4.01
F (%)		61.54

^aCompounds were formulated in 5% DMSO, 40% PEG400, and 55% (saline).

^bDose of 2 mg/kg.

^cDose of 10 mg/kg. Values are given as mean of three independent experiments.