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Multivalent G4 binding by muRif1 oligomer could mediate association between distant chromatin loci. A, schematic representation of at least two G4-binding and oligomerization domains present in the N- and C-terminal segments of muRif1. B, model on G4-based assembly of multiple chromatin fibers mediated by Rif1 that binds to multiple G4-containing DNA due to its oligomeric structure.
