Figure 1.

Anti-tuberculosis efficacy of rifampicin, isoniazid, and ethambutol against the intracellular survival of M. tuberculosis in macrophages isolated from drug responders and nonresponders. A, intracellular survival of drug-susceptible M. tuberculosis in hMDMs of TB drug responding (n = 8) or nonresponding (n = 8) patients in the absence or presence of frontline anti-TB drugs (rifampicin, isoniazid, or ethambutol) for 48 h. B, intracellular bacterial load in hMDMs of responders and nonresponders following 4 h of infection in the absence of drug. Bacterial survival was measured by a cfu assay. Horizontal lines represent the mean. *, p < 0.05 by the Mann-Whitney test; NS, non significant.