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. 2018 Mar 9;293(10):3588. doi: 10.1074/jbc.W118.002430

Anti-microRNA-222 (anti-miR-222) and -181B suppresses growth of tamoxifen-resistant xenografts in mouse by targeting TIMP3 protein and modulating mitogenic signal.

Yuanzhi Lu, Satavisha Roy, Gerard Nuovo, Bhuvaneswari Ramaswamy, Tyler Miller, Charles Shapiro, Samson T Jacob, Sarmila Majumder
PMCID: PMC5846153  PMID: 29523694

VOLUME 286 (2011) PAGES 42292–42302

This article has been withdrawn by the authors. The Journal raised questions regarding Figs. 5C, 5D, 6A, 6B, 6C, 6D, 7A, 7C, 7D, 8E, and S3. The authors were able to locate some, but not all, of the original data and were able to locate some repeat experiments performed at the time of the original work, which the authors state support the conclusions of the paper. The authors state that the results of this paper are confirmed by the results of complementary experiments presented in the manuscript and that the principal observation of this paper was further confirmed in a 2014 paper (PMID Medline), in which tamoxifen resistance in breast cancer was connected to miR-221/222, by suppression of TIMP3. The authors stand by the reproducibility of the experimental data and the conclusions of the paper.


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