Table 1.

iTRAQ-based relative ratios of peptides/proteins identified by GST pulldown

Cross-comparison ratios of iTRAQ-labeled peptides were determined by ProteinPilot software and analyzed using MATLAB. Ratios are averaged across 4 biological replicates. A protein had to show the same deregulation trend in at least 2 of the 4 replicates to be considered as deregulated with a p value <0.05. Ratios of >1.2 for increased interactions or <0.82 for reduced interactions were used as cut-off from our previous work using iTRAQ (26).

UNIPROT ID	Protein name	Total (ID confidence)	Distinct peptides	tauΔ18–28:tauFL mean ratio (n = 4)	p value (n = 4 replicates)
1433E_MOUSE	14-3-3 β	8.28	6	1.68	0.016
1433B_MOUSE	14-3-3 β	10.12	10	1.51	0.014
NEUG_MOUSE	Neurogranin	4.00	2	0.78	0.003
SYT1_MOUSE	Synaptotagmin-1	2.85	2	0.77	0.025
NEUM_MOUSE	Neuromodulin/growth associated protein 43	6.42	3	0.77	0.044
SYN1_MOUSE	Synapsin-1	7.54	4	0.73	0.038
ANXA5_MOUSE	Annexin A5/Lipocortin V	2.09	2	0.59	0.014