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. 2018 Mar 6;11:1275–1284. doi: 10.2147/OTT.S154517

Figure 1.

Figure 1

miR-302b-3p/302c-3p/302d-3p is downregulated in EC, inhibits the EMT process and reduces the expression of ZEB1.

Notes: (A) qRT-PCR revealed the expression of miR-302b-3p, miR-302c-3p and miR-302d-3p in 30 pairs of human EC and normal endometrial tissues. GAPDH was used as the internal control. (B) The impact of miR-302b-3p/302c-3p/302d-3p mimics and inhibitors on the relative expression of proteins in the EMT process in Ishikawa and HEC-1A cells, as detected by Western blot. GAPDH was used as the internal control. (C) Statistical analysis of the relative expression of proteins in the EMT process in Ishikawa and HEC-1A cells. (D) MiR-302b-3p/302c-3p/302d-3p mimics and inhibitors regulate the expression of ZEB1, as determined by qRT-PCR in Ishikawa and HEC-1A cells. GAPDH was used as the internal control. Data are presented as the mean ± SD values of three independent experiments. *P<0.05, **P<0.01, and ***P<0.001.

Abbreviations: EC, endometrial carcinoma; EMT, epithelial–mesenchymal transition; NC, normal control; qRT-PCR, quantitative reverse transcription polymerase chain reaction.