Table 4.
Sensitivity analysis
| Variables | Before matching
|
After matching
|
||
|---|---|---|---|---|
| Crude
|
Adjusteda
|
Crude
|
Adjusteda
|
|
| HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) | |
| Primary analysis | ||||
| Mortality | 1.5 (1.42–1.57) | 1.29 (1.22–1.37) | 1.33 (1.25–1.42) | 1.33 (1.26–1.42) |
| Pneumonia | 1.3 (1.24–1.36) | 1.2 (1.14–1.26) | 1.22 (1.15–1.29) | 1.22 (1.15–1.29) |
| Pneumonia requiring MV | 1.47 (1.37–1.58) | 1.34 (1.24–1.45) | 1.35 (1.23–1.47) | 1.35 (1.24–1.47) |
| ITT analysis + competing risk | ||||
| Mortality | ||||
| Pneumonia | 1.04 (1–1.09) | 1.15 (1.09–1.2) | 1.19 (1.13–1.26) | 1.19 (1.13–1.26) |
| Pneumonia requiring MV | 0.96 (0.92–1) | 1.15 (1.09–1.2) | 1.19 (1.12–1.25) | 1.19 (1.13–1.25) |
| As-treated analysis | ||||
| Mortality | 1.5 (1.4–1.61) | 1.28 (1.19–1.38) | 1.29 (1.19–1.4) | 1.3 (1.2–1.41) |
| Pneumonia | 1.28 (1.21–1.36) | 1.17 (1.1–1.26) | 1.16 (1.08–1.25) | 1.17 (1.09–1.26) |
| Pneumonia requiring MV | 1.38 (1.25–1.52) | 1.25 (1.13–1.39) | 1.21 (1.07–1.36) | 1.21 (1.08–1.37) |
| As-treated analysis + competing risk | ||||
| Mortality | ||||
| Pneumonia | 1.07 (1.01–1.13) | 1.06 (1–1.12) | 1.07 (1–1.15) | 1.08 (1.01–1.15) |
| Pneumonia requiring MV | 1.01 (0.96–1.07) | 1.03 (0.97–1.1) | 1.04 (0.98–1.12) | 1.04 (0.97–1.12) |
Note:
a
Adjusted for propensity score.
Abbreviations: HR, hazard ratio; ITT, intention-to-treat; MV, mechanical ventilation.