Table 3.
Regions negatively related to ROIs (8 mm in diameter) centered in the ventral anterior cingulate cortex (Talairach coordinates: x = 2, y = 38, z = -2) and posterior cingulate cortex (Talairach coordinates: x = 2, y = -51, z = 27) in crack-cocaine users (n = 8) and age-matched non-drug-using controls (n = 8).
| ROI | Group or comparison | Cluster | Voxels | P | Max z | Talairach coordinates | Brodmann's area or region | ||
|---|---|---|---|---|---|---|---|---|---|
| x | y | z | |||||||
| Ventral anterior cingulate cortex | Control | 1 | 581 | 0.0334 | 3.46 | -22 | 2 | 70 | 6 (left superior frontal gyrus) |
| 2 | 1,643 | 1.55 × 10-5 | 3.79 | 22 | 2 | 62 | 6 (right superior frontal gyrus) | ||
| 3 | 4,675 | 2.85 × 10-12 | 3.52 | 2 | -74 | -38 | Right inferior semilunar lobule | ||
| 4 | 4,756 | 1.99 × 10-12 | 3.64 | -24 | -64 | 46 | 7 (left superior parietal lobule) | ||
| Crack-cocaine | 1 | 12,432 | 1.31 × 10-24 | 4.42 | -2 | -10 | 72 | 6 (left medial frontal gyrus) | |
| Group-level analysis | |||||||||
| Crack-cocaine > control | 1 | 585 | 0.0322 | 3.66 | -32 | -38 | 60 | 5 (left superior parietal lobule) | |
| Posterior cingulate cortex | Control | 1 | 655 | 0.0312 | 3.94 | -34 | 44 | 34 | 9 (left middle frontal gyrus) |
| 2 | 9,727 | 6.21 × 10-19 | 4.52 | 2 | 14 | 50 | 6 (right superior frontal gyrus) | ||
| Crack-cocaine | 1 | 2,049 | 5.3 × 10-6 | 4.53 | 58 | -28 | 30 | 40 (right inferior parietal lobule) | |
| 2 | 2,381 | 9.54 × 10-7 | 4.54 | -42 | 56 | 22 | 10 (left middle frontal gyrus) | ||
| 3 | 2,719 | 1.79 × 10-7 | 4.49 | 30 | 48 | 26 | 10 (right superior frontal gyrus) | ||
| 4 | 6,607 | 2.21 × 10-14 | 4.46 | -64 | -36 | 30 | 40 (left inferior parietal lobe) | ||