Table 1.
Cas9 delivery in different formats | ||||
---|---|---|---|---|
Viral | Plasmid | RNA | Protein | |
Insertional mutagenesis | High | Moderate | No | No |
Editing efficiency | High | Moderate | Moderate | High |
Off-target | Low | Moderate | Moderate | High |
Immunogenicity | High | Moderate | Moderate | Low |