. 2018 Feb 26;2018:5637130. doi: 10.1155/2018/5637130

Table 4.

Multivariate analysis using Cox's proportional regression analysis of any-diabetic retinopathy.

Variables	Model 1^∗	Model 2^∗∗	Model 3^∗∗∗	Model 4^∗∗∗∗
Current age	p < 0.001	p < 0.001	p < 0.001	p < 0.001
Current age	HR 1.136 (1.084–1.224)^†	HR 1.140 (1.081–1.227)	HR 1.140 (1.072–1.284)	HR 1.145 (1.083–1.290)

Sex	p = 0.065	p = 0.077	p = 0.070	p = 0.073
Sex	HR 0.761 (0.643–0.961)	HR 0.822 (0.668–1.060)	HR 0.820 (0.651–1.072)	HR 0.834 (0.644–1.015)

Insulin treatment	p < 0.001	p < 0.001	p < 0.001	p < 0.001
Insulin treatment	HR 1.218 (1.131–1.448)	HR 1.302 (1.188–1.506)	HR 1.311 (1.174–1.501)	HR 1.302 (1.178–1.545)

Arterial hypertension	p = 0.05	p = 0.05	p = 0.045	p = 0.049
Arterial hypertension	HR 1.118 (0.985–1.788)	HR 1.121 (0.907–1.340)	HR 1.134 (1.002–1.161)	HR 1.367 (1.062–1.899)

HbA1c	p < 0.001	P < 0.001	p < 0.001	p < 0.001
HbA1c	HR 2.135 (1.893–2.408)	HR 2.089 (1.811–2.632)	HR 2.052 (1.780–2.273)	HR 2.037 (1.806–2.297)

eGFR < 60 ml/min/1.73 m²		p = 0.002	p = 0.04	p = 0.09
eGFR < 60 ml/min/1.73 m²		HR 1.854 (1.251–4.431)	HR 1.223 (1.098–1.201)	HR 1.103 (0.078–1.311)

UACR ≥ 30 mg/g			p < 0.001	P = 0.004
UACR ≥ 30 mg/g			HR 1.485 (1.103–1.548)	HR 1.485 (1.092–1.465)

UACR ≥ 300 mg/g and eGFR< 30 ml/min/1.73 m²				p < 0.001
UACR ≥ 300 mg/g and eGFR< 30 ml/min/1.73 m²				HR 1.998 (1.682–2.305)

Model 1^∗, Cox's analysis in which the variables of renal function are not included; model 2^∗∗, Cox's analysis in which we include only the eGFR variable for the study of renal function; model 3^∗∗∗, Cox's analysis with eGFR and UACR as variables for the study of renal function; model 4^∗∗∗∗, Cox's analysis in which we included in addition to the eGFR and the UACR, the presence of renal failure. ^†Hazard ratio (95% CI).