Table 6.
Multivariate analysis using Cox's proportional regression analysis of STDR and DME.
| STDR | DME | |
|---|---|---|
| Variables | Significance | Significance |
| Hazard ratio (95% CI)∗ | Hazard ratio (95% CI) | |
|
| ||
| Current age | p = 0.018 | p = 0.057 |
| HR 0.991 (0.984–0.999) | HR 0.993 (0.986–1.000) | |
|
| ||
| Sex | p < 0.001 | p < 0.001 |
| HR 0.644 (0.531–0.781) | HR 0.655 (0.539–0.794) | |
|
| ||
| Insulin treatment | p = 0.01 | p = 0.01 |
| HR 1.313 (1.123–1.535) | HR 1.308 (1.117–1.530) | |
|
| ||
| Arterial hypertension | p < 0.001 | p < 0.001 |
| HR 2.128 (1.726–2.623) | HR 2.126 (1.721–2.626) | |
|
| ||
| HbA1c | p < 0.001 | p < 0.001 |
| HR 3.230 (2.378–4.387) | HR 3.194 (2.350–4.340) | |
|
| ||
| eGFR < 60 ml/min/1.73 m2 | p = 0.07 | p = 0.09 |
| HR 1.097 (0.899–1.979) | HR 1.033 (0.877–1.972) | |
|
| ||
| UACR ≥ 30 mg/g | p = 0.004 | p = 0.006 |
| HR 2.099 (1.163–3.072) | HR 1.978 (1.237–2.901) | |
|
| ||
| UACR ≥ 300 mg/g and eGFR < 30 ml/min/1.73 m2 | p < 0.001 | p < 0.001 |
| HR 3.174 (2.140–4.708) | HR 3.190 (2.150–4.732) | |
∗Hazard ratio (95% confidence interval). STDR: sight threatening diabetic retinopathy; DME: diabetic macular edema. ∗Hazard ratio (95%CI).