Figure 2.

In vivo imaging of GFP-labeled RPE cells transplanted into the subretinal space of non–immune-suppressed rhesus monkeys using color fundus photography, FAF, and OCT at 4 days and 1, 2, and 3 weeks posttransplantation. In the representative color fundus images, white subretinal material was present at 4 days and evolved in shape and appearance over subsequent weeks. The GFP fluorescence of the transplanted cells was evident at 4 days but extinguished by 2 weeks. Subretinal debris, fibrotic scarring, and mononuclear cells, as confirmed by histology, resulted in OCT images that showed material in the subretinal space that without confirmation through histologic study could be misinterpreted as the transplanted RPE cells.