Figure 5.

Brain volume loss in the placebo population as a function of (A) the baseline T2 lesion volume in patients without baseline Gd+ lesions, and (B) the baseline Gd+ lesion count. In a predefined random coefficient model, percentage brain volume loss depended strongly on baseline T2 volume (P < 0.0001), but not or only marginally on other covariates (e.g., number of Gd+ lesions at baseline, P = 0.145). *Categories for baseline Gd+ lesions and T2 volume were based on those previously used in RRMS (Haering DA, unpublished data). Similar results were obtained using T2 volume quartiles. ^†Proposed cutoff discriminating pathologic from physiologic rate of brain volume loss (0.37% per year).16