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. 2018 Jan 30;5(3):346–356. doi: 10.1002/acn3.534

Table 2.

Baseline normalized brain volume as a function of age, gender, and baseline MS disease characteristics

Predictor Coefficienta t‐value P‐value
Demographics
Age, per year −3.65 −11.8 <0.0001
Male sex 11.26 2.16 0.030
Baseline disease characteristics
T2 volumeb −37.79 −11.9 <0.0001
EDSS −2.75 −1.1 0.281
Duration of MSc −0.586 −0.18 0.856
Entire modeld SDresiduals 73 cm3 Intercept 1742 cm3 <0.0001

This analysis was prespecified before database lock and includes the entire study population (before first dose, irrespective of treatment allocation) using the same multiple regression model and covariates previously used in RMS.6 SD, standard deviation.

a

Coefficient, predicted change in normalized brain volume (in cm3) per unit change in the given predictor when all other predictors are kept constant.

b

Tertiles: <2.8, 2.8–9.6, >9.6 cm3.

c

Tertiles: <4.52, 4.52–6.83, >6.83 years.

d

Unadjusted r 2 of the entire model: 26.4%.