Table 2.
Baseline normalized brain volume as a function of age, gender, and baseline MS disease characteristics
| Predictor | Coefficienta | t‐value | P‐value |
|---|---|---|---|
| Demographics | |||
| Age, per year | −3.65 | −11.8 | <0.0001 |
| Male sex | 11.26 | 2.16 | 0.030 |
| Baseline disease characteristics | |||
| T2 volumeb | −37.79 | −11.9 | <0.0001 |
| EDSS | −2.75 | −1.1 | 0.281 |
| Duration of MSc | −0.586 | −0.18 | 0.856 |
| Entire modeld | SDresiduals 73 cm3 | Intercept 1742 cm3 | <0.0001 |
This analysis was prespecified before database lock and includes the entire study population (before first dose, irrespective of treatment allocation) using the same multiple regression model and covariates previously used in RMS.6 SD, standard deviation.
a
Coefficient, predicted change in normalized brain volume (in cm3) per unit change in the given predictor when all other predictors are kept constant.
b
Tertiles: <2.8, 2.8–9.6, >9.6 cm3.
c
Tertiles: <4.52, 4.52–6.83, >6.83 years.
d
Unadjusted r 2 of the entire model: 26.4%.