Table 1.
Demographics
| Sex – Female (%) | 50% |
| Age (years): Median (IQR; min/max) | 58 (29; 6/96) |
| Weight (kg) Median (IQR; min/max) | 75 (27; 22/159) |
| PHT vs. FOS used for loading dose | 41(8%)/453(92%) |
| Loading dose (mg) | |
| Median (IQR; min/max) | 1378 (629; 500/2614) |
| Mean | 1356 |
| Loading dose (mg/kg) | |
| Median (IQR; min/max) | 19 (5; 4/31) |
| Mean | 18 |
| Maintenance dose (MD), Mean (mg) | 112 |
| Weight adjusted maintenance dose, Mean (mg/kg) | 1.5 |
| Additional Loading dose, Mean (mg) | 931 |
| Weight adjusted additional Loading dose, Mean (mg/kg) | 11 |
| Timing in hours of the serum lab draw following a loading dose, Mean (Min/Max) | |
| LD Only | 7 (2/24) |
| LD + MD(s) | 16 (5/24) |
| Multiple LDs | 13 (2/24) |
| Timing in hours of the serum lab draw following last PHT dose, Mean (Min/Max) | |
| LD + MD(s) | 5 (2/13) |
| Multiple LDs | 7 (2/21) |
| Diagnoses on admission | |
| Known seizure disorder/Epilepsy | 158 |
| Altered mental status | 42 |
| Traumatic brain injury/Trauma | 35 |
| Intracerebral hemorrhage | 34 |
| Subdural hematoma | 24 |
| Brain mass (primary or secondary) | 24 |
| Acute stroke | 19 |
| Subarachnoid hemorrhage | 15 |
| Infectious meningitis/Encephalitis | 8 |
| Cardiac arrest | 5 |
| Epidural hematoma | 4 |
| Other medical conditions (*) | 93 |
(*) Other conditions registered as the primary diagnosis included urinary tract infections, asphyxiation, long bone fractures, pseudo-seizure, gunshot to the abdomen, etc. See Supplemental data for further details and the list of secondary and tertiary diagnoses.