Table 2. Total Phenytoin (tPHT) serum levels for a given cumulative PHT/Fosphenytoin dose conditional on the time of blood draw from the initial loading dose for each of the medication groups. Please use colors for publication.
The numbers reflect tPTH serum levels divided as <10/10–20/≥ 20 μg/mL. Subgroup totals are in parentheses. (LD= Loading Dose; MD= Maintenance Dose). Colored are the groups with statistically significant difference.
| PHT/FOS Dosing Groups (Number of values) | Cumulative PHT/FOS dose [mg/kg) and total number of values (N) | 2–6 hours post LD | 6–10 hours post LD | 10–14 hours post LD | 14–18 hours post LD | 18–20 hours post LD | 20–24 hours post LD |
|---|---|---|---|---|---|---|---|
| LD only (355) | |||||||
| [3,15) (79) | 6/24/4 | 4/16/2 | 3/2/- | 3/5/- | 2/3/- | 3/2/- | |
| [15,20) (202) | 7/69/42 | 3/36/11 | -/8/8 | 3/9/1 | 1/1/- | 1/2/- | |
| [20,55) (74) | 1/19/19 | -/12/8 | 1/5/2 | 2/2/- | -/1/- | 1/1/- | |
| LD+MD(s) (137) | |||||||
| [3,15) (12) | -/-/- | -/1/1 | -/2/- | 3/3/- | -/-/- | 1/1/- | |
| [15,20) (42) | -/1/- | -/-/1 | -/12/4 | 1/11/- | 2/2/- | 3/5/- | |
| [20,55) (83) | -/-/1 | -/2/8 | 2/9/11 | 1/15/2 | -/4/2 | 4/16/6 | |
| Multiple LDs (53) | |||||||
| [3,15) (7) | -/-/- | -/1/- | 1/1/- | -/1/- | -/1/- | 1/-/1 | |
| [15,20) (8) | -/-/- | -/1/- | -/2/- | -/2/- | -/-/- | -/3/- | |
| [20,55) (38) | -/2/3 | 1/5/3 | -/10/3 | -/4/2 | -/1/- | -/4/- |