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Effect of stimulation frequency on dopamine release. The stimulation frequency was increased while stimulation pulses and width were kept constant (120 pulses, 4 ms pulse duration). Evoked dopamine release was measured both in whole brain and sagittal slices. A linear regression was done for both preparations. The whole brain data had a significant non-zero slope (R2 = 0.96, p = 0.003) while the slice preparation was found to have no significant slope (R2 = 0.17, p = 0.49).
