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. Author manuscript; available in PMC: 2018 Mar 12.
Published in final edited form as: Sci Transl Med. 2017 Jul 12;9(398):eaal1243. doi: 10.1126/scitranslmed.aal1243

Fig. 5. Induction of lung-restricted autoimmunity and OAD by Ab ligation of AM MHC class I is Zbtb7a dependent.

Fig. 5

(A) AM surface expression of lineage markers and H-2Kd transgene in huCD68-Kd Tg C57BL/6. (B) Representative trichrome stained images showing fibrotic scar and occluded bronchiole in anti-H-2Kd induced OAD, day 30 (n=7) and (C) histopathology assessment of the OAD lesion. Development of de novo Ab titers (D) and stimulation of Th17 cells (E) specific for Kα1T and Col V were evaluated on day 30. (F) Surface expression of MHC (class I and II) and co-stimulatory molecules in Zbtb7a-sufficient or Zbtb7a-deficient AMs following anti-H-2Kd administration on day 30. Data were analyzed by multiple t-tests and statistical significance (*) was determined using the Holm-Sidak method, with p<0.05. Scale bar in panel B is 100µm; b, bronchiole; o, occluded bronchiole.