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. Author manuscript; available in PMC: 2018 Mar 12.
Published in final edited form as: Sci Transl Med. 2017 Jul 12;9(398):eaal1243. doi: 10.1126/scitranslmed.aal1243

Fig. 8. Zbtb7a deficiency in AMs impairs antigen presentation.

Fig. 8

Adoptively transferred Zbtb7a-sufficient or -deficient huCD68-Kd Tg AMs in Fig. 6 were antigen pulsed (with L-OVA or L-BSA delivering 5µg of protein, or 1µg of OVA 323–339 peptide) in vivo at 15 wks post transfer, harvested at 6 h post pulsing and co-transferred (1×105) with 5×106 CFSE labeled naïve OT-II TCR transgenic T cells. Proliferation of OT-II T cells in lungs and spleen were measured by CFSE dilution at 72 h by gating on CFSE+, CD3+ T cells (n=5).