Table 1.

Clinical and optical variables for each individual patient and also for the group.

Case			1	2	3	4	5	All
Age (y), Sex(M/F)			80, F	58, M	93, F	80, M	92, F	81 ± 14
Arterial occlusion			Left MCA (distal)	Right MCA (prox.)	Left MCA (prox.)	Right MCA (prox.)	Right MCA (prox.)
NIHSS		Pre-rtPA	15	16	22	21	19	19±3
		Post-rtPA	–	14	5	13	9	10±4
		24h	3	8	2	4	1	4±3
Recanalization			Unkn.	Yes	Yes	Yes	Yes
mRS 90 days			1	2	3	1	1	2±1
Slope of the linear model	ΔrCBF $\left(\frac{\%}{\mathit{\text{min}}}\right)$	Ipsi-side	0.17†	0.54†	0.45†	0.23†	0.023	0.29†‡
		Contra-side	0.085	0.33†	0.32†	0.013	−0.00080	0.16†
	ΔTHC $\left(\frac{\mu M}{\mathit{\text{min}}}\right)$	Ipsi-side	0.023†	0.035†	0.063†	0.030†	0.0055†	0.041†‡
		Contra-side	−0.0051	0.0023	0.030†	0.029†	0.041†	0.019†
	ΔHbO2 $\left(\frac{\mu M}{\mathit{\text{min}}}\right)$	Ipsi-side	0.046†	0.053†	0.059†	0.026†	0.050†	0.047†‡
		Contra-side	0.00060	0.026†	0.031†	0.019†	0.047†	0.025†
	ΔHb $\left(\frac{\mu M}{\mathit{\text{min}}}\right)$	Ipsi-side	−0.023†	−0.018†	0.0031†	0.0042†	0.0050	−0.0056
		Contra-side	−0.0057	−0.024†	−0.0015	0.010†	−0.0063†	−0.0053

(Δ) indicates a change of each optical variable from the baseline (within fifteen minutes from rtPA bolus) to the end of the monitoring (∼2.5 hours). † indicates a statistically significant slope. ‡ indicates a statistically significant difference between ipsi- over contra-lesional side as a group. M=male. F= female. NIHSS=National Institutes of Health Stroke Scale. mRS=modified Rankin scale. rCBF=relative cerebral blood flow. THC=total hemoglobin concentration. HbO₂=oxy-hemoglobin. Hb=deoxy-hemoglobin. Ipsi=ipsilesional. Cont.=contralesional. Prox.=proximal. Unkn.=unknown. Mean ± standard deviation.