Table 3.

Clinical Outcomes According to Assigned Treatment Group in the Intention-to-Treat Analysis.

Outcome	Balanced Crystalloids (N = 6708)	Saline (N = 6639)	Adjusted Odds Ratio (95% CI)*	Adjusted P Value
Median hospital-free days to day 28 (IQR)	25 (22–26)	25 (22–26)	0.98 (0.92–1.04)	0.41
Major adverse kidney event within 30 days — no. (%)	315 (4.7)	370 (5.6)	0.82 (0.70–0.95)	0.01
Death — no. (%)	94 (1.4)	102 (1.5)	0.89
New renal-replacement therapy — no./total no. (%)†	18/6582 (0.3)	31/6530 (0.5)	0.56
Final serum creatinine ≥200% of baseline — no./total no. (%)†	253/6582 (3.8)	293/6530 (4.5)	0.84
Stage 2 or higher acute kidney injury — no./total no. (%)†	528/6582 (8.0)	560/6530 (8.6)	0.91 (0.80–1.03)	0.14
In-hospital death — no. (%)	95 (1.4)	105 (1.6)	0.88 (0.66–1.16)	0.36

^*Multivariable models were adjusted for age, sex, race, admitting service, and time (days since trial initiation).

^†Patients with end-stage renal disease who were receiving long-term renal-replacement therapy at the time of emergency department arrival (126 in the balanced-crystalloids group and 109 in the saline group) were not eligible for the following outcomes: new renal-replacement therapy within 30 days, final serum creatinine concentration within 30 days at least 200% of the baseline value, and stage 2 or higher acute kidney injury.