Table II.
Results of gene set enrichment analysis performed on differentially expressed genes and GO BP terms.
| A, (MAF and ACF) vs. CDF
| |||
|---|---|---|---|
| GO BP ID | Term | Overlap | Adjusted P-value |
| GO:0030198 | Extracellular matrix organization | 35/359 | 0.00091 |
| GO:0043062 | Extracellular structure organization | 35/360 | 0.00091 |
| GO:0001936 | Regulation of endothelial cell proliferation | 15/88 | 0.00335 |
| GO:0010574 | Regulation of vascular endothelial growth factor production | 8/27 | 0.01791 |
| GO:0002237 | Response to molecule of bacterial origin | 24/243 | 0.01791 |
| GO:0009611 | Response to wounding | 19/167 | 0.01791 |
| GO:0051272 | Positive regulation of cellular component movement | 27/296 | 0.01791 |
| GO:0040017 | Positive regulation of locomotion | 27/304 | 0.02116 |
| GO:2000147 | Positive regulation of cell motility | 26/287 | 0.02116 |
| GO:0001503 | Ossification | 15/116 | 0.02116 |
| GO:0008347 | Glial cell migration | 6/15 | 0.02116 |
| GO:0045765 | Regulation of angiogenesis | 19/179 | 0.02490 |
| GO:0032496 | Response to lipopolysaccharide | 22/228 | 0.02490 |
| GO:0030335 | Positive regulation of cell migration | 25/280 | 0.02511 |
| GO:0030111 | Regulation of Wnt signaling pathway | 21/214 | 0.02515 |
| GO:0060828 | Regulation of canonical Wnt signaling pathway | 17/152 | 0.02544 |
| GO:0051894 | Positive regulation of focal adhesion assembly | 6/18 | 0.02978 |
| GO:1901890 | Positive regulation of cell junction assembly | 6/18 | 0.02978 |
| GO:0001937 | Negative regulation of endothelial cell proliferation | 7/27 | 0.02978 |
| B, (CDF and ACF) vs. MAF
| |||
|---|---|---|---|
| GO BP ID | Term | Overlap | Adjusted P-value |
| GO:0048729 | Tissue morphogenesis | 44/358 | 0.00023 |
| GO:0051272 | Positive regulation of cellular component movement | 39/296 | 0.00023 |
| GO:0030198 | Extracellular matrix organization | 44/359 | 0.00023 |
| GO:0043062 | Extracellular structure organization | 44/360 | 0.00023 |
| GO:2000147 | Positive regulation of cell motility | 37/287 | 0.00055 |
| GO:0030335 | Positive regulation of cell migration | 36/280 | 0.00068 |
| GO:0048598 | Embryonic morphogenesis | 45/403 | 0.00094 |
| GO:0040017 | Positive regulation of locomotion | 37/304 | 0.00118 |
| GO:0030155 | Regulation of cell adhesion | 39/336 | 0.00158 |
| GO:0002009 | Morphogenesis of an epithelium | 35/296 | 0.00312 |
| GO:0048562 | Embryonic organ morphogenesis | 20/121 | 0.00400 |
| GO:0048704 | Embryonic skeletal system morphogenesis | 16/81 | 0.00403 |
| GO:0045785 | Positive regulation of cell adhesion | 24/171 | 0.00507 |
| GO:0036293 | Response to decreased oxygen levels | 30/245 | 0.00507 |
| GO:0009887 | Organ morphogenesis | 42/405 | 0.00507 |
| GO:0070482 | Response to oxygen levels | 31/259 | 0.00516 |
| GO:0071294 | Cellular response to zinc ion | 7/14 | 0.00770 |
| GO:0001666 | Response to hypoxia | 29/241 | 0.00770 |
| GO:0022617 | Extracellular matrix disassembly | 18/116 | 0.01315 |
| GO:0048705 | Skeletal system morphogenesis | 17/106 | 0.01380 |
The 'best' 20 ontology terms are provided for each comparison (i.e. corresponds to the terms with an adjusted P-value of the enrichment test ≥0.03). GO BP, gene ontology biological process; MAF, melanoma-associated fibroblast; ACF, autologous control fibroblast; CDF, control dermal fibroblast.