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. 2018 Feb 5;41(5):2704–2714. doi: 10.3892/ijmm.2018.3457

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Copyright: © Ling et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Protein expression of α-SMA, vimentin, PODXL1 and nephrin, as examined by immunohistochemical assay. The α-SMA and vimentin expression levels were almost absent in the control group, but were highly expressed in diabetic kidneys at 1 and 6 weeks. However, PODXL1 and nephrin were intensely expressed in the control rats, but markedly downregulated in the kidneys following STZ injection. All experiments were performed in triplicate, and representative immunohistochemistry images are shown. α-SMA, α-smooth muscle actin; PODXL1, podocalyxin-like 1; STZ, streptozocin.