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. 2018 Feb 16;41(5):2629–2639. doi: 10.3892/ijmm.2018.3501

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Copyright: © Li et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Assessment of renal injury in diabetic rats. Diabetic rats showed a significant increase in fasting blood glucose (FBG), serum creatinine (Scr), blood urea nitrogen (BUN) (A) as well as glycosuria (GLU), microalbumin (MAU), albumin to creatinine ratio (ACR) and urine volume (UV) (B) at 4 weeks after streptozotocin (STZ) injection. Hematoxylin and eosin (H&E) and periodicacid-Schiff (PAS)-stained sections of renal cortices at 8 weeks (C) after diabetes onset showed obvious morphologic lesions in kidney of diabetic rats, including glomerular hypertrophy, increased fractional mesangial area and tubular dilatation [(C) magnification, ×400] [^*p<0.05 vs. normal group (NC)].