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. 2018 Feb 13;41(5):2609–2618. doi: 10.3892/ijmm.2018.3489

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Copyright: © Liu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Alterations in I_h properties of bladder interstitial cells of Cajal-like cells (ICC-LCs) from spinal cord injury (SCI) rats. (A) Upon a voltage-clamp protocol with a holding potential of −60 mV and a stepped potential from −60 to −120 mV in increments of −10 mV, characteristic I_h was recorded in bladder ICC-LCs from all three groups. ZD7288 (50 µM) significantly reduced the I_h amplitude in all three groups, which confirmed the specificity of these recorded I_h. (B) When HCN channels were fully activated at the potential of −120 mV, the I_h amplitude and the HCN channel gating rate were significantly declined in SCI rats. (C and D) Compared with that in control and sham rats, the I_h density normalized to cell capacitance was significantly decreased in SCI rats, over the voltage range of −60 to −120 mV (^*P<0.05, ^**P<0.01 and ^***P<0.001).