Table 1.
Molecules in the BMP, TGF-β, and activin signaling pathway in mammals and Drosophila
| Mammals | Drosophila | |
|---|---|---|
| Ligands | ||
| BMP | BMP2, BMP4 | Dpp |
| GDF5, GDF6, GDF7 | Gbb | |
| BMP5, BMP6, BMP7, BMP8 | ||
| GDF1, GDF2, GDF3 | Scw | |
| BMP9, BMP10 | ||
| BMP3, GDF10 | ||
| Nodal | ||
| TGF-β | TGF-β1, TGF-β2, TGF-β3 | Mav |
| Lefty1, Lefty2 | ||
| Activin | ActivinA, ActivinB, ActivinC, ActivinE | Act-β, Daw |
| InhivinA, InhibinC, InhibinE | Myo | |
| Type I receptors | ||
| BMP | ACVRL1 (ALK1), ACVRI (ALK2) | Sax |
| BMPR1A (ALK3), BMPR1B (ALK6) | Tkv | |
| TGF-β | TβRI (ALK5), ACVRL1 (ALK1) | BaboA, BaboB, BaboC |
| Activin | ACVR1B (ALK4), ACVR1C (ALK7) | BaboA, BaboB, BaboC |
| Type II receptors | ||
| BMP | BMPR2 | Wit |
| ACVRIIA (ACTRIIA), ACVRIIB (ACTRIIB) | Punt | |
| TGF-β | TβRII | Punt |
| Activin | ACVRIIA (ACTRIIA), ACVRIIB (ACTRIIB) | Punt |
| R-Smads | ||
| BMP | Smad1, Smad5, Smad8 | Mad |
| TGF-β | Smad2, Smad3 | Smox |
| Activin | Smad2, Smad3 | Smox |
| Co-Smads | ||
| BMP | Smad4 | Medea |
| TGF-β | Smad4 | Medea |
| Activin | Smad4 | Medea |
| I-Smads | ||
| BMP | Smad6, Smad7 | Dad |
| TGF-β | Smad7 | Dad |
| Activin | Smad7 | Dad |