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. 2018 Mar 12;13(3):e0192963. doi: 10.1371/journal.pone.0192963

Fig 3. Co-localization of TMPRSS4, tryptase and chymase in IPF and control lungs.

Fig 3

Representative images of immunofluorescence staining performed with specific antibodies against each molecule in lung tissue sections from IPF patients. Top and central row: IPF tissues coexpressing TMPRSS4 and tryptase or chymase; bottom row: normal lung showing no expression. Tissues were stained for TMPRSS4 (Dylight-549, red), tryptase (AF-488, green upper panel) and chymase (AF-647, green middle panel). The colocalization of TMPRSS4 and tryptase or chymase was determined by fluorescence microscopy and images were merged to resolve the co-localization of these proteins. Co-localization of TMPRSS4 was observed with both triptase and chymase. Data are representative of three independent experiments.